Effects of Ticagrelor on Myocardial Infarct Size
نویسندگان
چکیده
منابع مشابه
Effects of Ticagrelor on Myocardial Infarct Size
Ticagrelor (Brilinta; AstraZeneca Pharmaceuticals LP, Wilmington, DE, USA) is a direct acting, reversible, oral P2Y12 inhibitor.1) In the PLATelet inhibition and patient Outcomes (PLATO) study, compared to clopidogrel (Plavix; Bristol-Myers Squibb/Sanofi Pharmaceuticals, Bridgewater, NJ, USA), ticagrelor reduced the rate of death from vascular causes, myocardial infarction (MI), or stroke in pa...
متن کاملEffects of hydroalcoholic extract from aerial parts of the sterile stems of Stachys inflata on myocardial infarct size in rats
Recently a potent anti-inflammatory effect of hydroalcoholic extract of the aerial parts of the sterile stems of Stachys inflata has been reported. This study examined whether hydroalcoholic extract isolated from aerial parts of non-flowering stems of Stachys inflata (standardized to contain 4.5% caffeic acid derivatives) reduce myocardial infarct size arising from coronary artery occlusion (30...
متن کاملEffects of hydroalcoholic extract from aerial parts of the sterile stems of Stachys inflata on myocardial infarct size in rats
Recently a potent anti-inflammatory effect of hydroalcoholic extract of the aerial parts of the sterile stems of Stachys inflata has been reported. This study examined whether hydroalcoholic extract isolated from aerial parts of non-flowering stems of Stachys inflata (standardized to contain 4.5% caffeic acid derivatives) reduce myocardial infarct size arising from coronary artery occlusion (30...
متن کاملChronic treatment with ticagrelor limits myocardial infarct size: an adenosine and cyclooxygenase-2-dependent effect.
OBJECTIVE In a phase III clinical trial (PLATelet inhibition and patient Outcomes, PLATO), ticagrelor provided better clinical outcomes than clopidogrel in patients with acute coronary syndromes. In addition to P2Y12-receptor antagonism, ticagrelor prevents cell uptake of adenosine and has proven able to augment adenosine effects. Adenosine protects the heart against ischemia-reperfusion injury...
متن کاملRelationship Between Myocardial Infarct Size
We compared myocardial infarct size produced by permanent occlusion of the middle left anterior descending (LAD) or circumflex (LCx) coronary artery in the anesthetized dog. The dogs were killed 3-10 days later, and the occluded coronary bed was visualized by postmortem arteriography. The outlines of the infarct and occluded bed were marked on tracings of weighed left ventricular (LV) rings and...
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ژورنال
عنوان ژورنال: Korean Circulation Journal
سال: 2017
ISSN: 1738-5520,1738-5555
DOI: 10.4070/kcj.2017.0161